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How is Addison disease recognized?

Added: 26 October 2026

Addison disease is primary adrenal insufficiency in which the adrenal glands do not produce enough cortisol and often aldosterone. Symptoms vary and overlap other conditions, so internet information alone should not be used for diagnosis.

Features, causes and evaluation

1. Features, causes and risks Persistent fatigue, weight loss, low blood pressure, salt craving, nausea and skin darkening may occur and can develop gradually. A risk factor does not guarantee disease, and its absence does not exclude disease. Onset, duration, triggers, medicines and coexisting conditions change the assessment. 2. Clinical evaluation A health professional starts with history and examination and selects laboratory or imaging tests according to the likely possibilities. One out-of-range result does not always prove disease, and a normal result may not exclude every possibility. Age, pregnancy, medicines and clinical context matter.

Follow-up, prevention and when to seek help

1. Follow-up, prevention and safety Cortisol, ACTH, electrolytes and stimulation testing require specialist interpretation. Vomiting, severe weakness, confusion and very low blood pressure may be adrenal crisis and are emergencies. Treatment depends on diagnosis, severity, other conditions, pregnancy, medicines and personal preferences. Starting, stopping or changing a prescription without professional advice can be unsafe. 2. When to seek help Seek care for new, persistent, worsening or function-limiting symptoms. Sudden breathlessness, chest pain, fainting, new weakness or speech difficulty, uncontrolled bleeding, severe dehydration, confusion or risk of self-harm requires emergency help. This is general information and not a personal medical assessment.

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Revision history

26 October 2026 — Article added.